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Optische Kohaerenztomografie in der Multiplen Sklerose

Item Type:Article
Title:Optische Kohaerenztomografie in der Multiplen Sklerose
Creators Name:Woelbert, M. and Brandt, A.U. and Paul, F. and Schippling, S.
Abstract:Multiple sclerosis (MS) is an inflammatory and degenerative autoimmune disease of the central nervous system. Magnetic resonance imaging allows the quantification of axonal and neuronal darnage by assessing the brain parenchymal fraction (BPF) and the extent of T1 hypointensities {black holes). Studies using optical coherence tomography (OCT) in MS consistently show increasing retinal nerve fiber layerthinning depending on the disease stage. PreHminary longitudinal data suggest that, irrespective of a history of optic neuritis, retinal nerve fiber layer thinning is increased during the course of MS beyond the level of what can be expected by normal aging.ln addition, measures of retinal atrophy correlate with the extent of cerebral atrophy as assessed by BPF in MRI. Further longitudinal and future interventional trials with latest OCT technology are mandatory to prove if OCT outcomes can be integrated as a surrogate for neurodegeneration in dinical MS trials.
Keywords:Multiple Sclerosis, Optical Coherence Tomography, Retinal Nerve Fiber Layer
Source:Nervenheilkunde
ISSN:0722-1541
Publisher:Schattauer (Germany)
Volume:30
Number:7
Page Range:493-497
Date:2011
Official Publication:http://www.schattauer.de/de/magazine/uebersicht/zeitschriften-a-z/nervenheilkunde/inhalt/archiv/issue/1420/manuscript/16325/show.html

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