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Vitamin D und Multiple Sklerose: Der Stellenwert fuer das Erkrankungsrisiko und die Behandlung [Vitamin D and multiple sclerosis: the role for risk of disease and treatment]

Item Type:Review
Title:Vitamin D und Multiple Sklerose: Der Stellenwert fuer das Erkrankungsrisiko und die Behandlung [Vitamin D and multiple sclerosis: the role for risk of disease and treatment]
Creators Name:Döring, A. and Paul, F. and Dörr, J.
Abstract:In addition to its important role in bone metabolism and calcium homeostasis an increasing number of beneficial effects are being attributed to vitamin D. Because of its suggested immunomodulatory capacity vitamin D deficiency or disturbance in the vitamin D metabolism might be a risk factor for the development of autoimmune diseases, such as multiple sclerosis; but supplementation with vitamin D might also be a therapeutic option. Substantial epidemiologic evidence indicates an association between vitamin D levels and risk of multiple sclerosis, suggesting vitamin D to be one of the long searched environmental factors for the development of this most common chronic inflammatory disease of the central nervous system. Less consistent are the available data for modification of the disease course in already established multiple sclerosis.This review highlights possible interactions between vitamin D and multiple sclerosis and focuses on its putative involvement in the pathogenesis and its possible role for treatment of multiple sclerosis. In particular the as yet insufficiently investigated therapeutic aspect is currently being addressed in several high quality clinical trials.
Keywords:Multiple Sclerosis, Vitamin D, Therapy , Risk of Disease, Prevention
Source:Nervenarzt
ISSN:0028-2804
Publisher:Springer (Germany)
Volume:84
Number:2
Page Range:173-189
Date:February 2013
Official Publication:https://doi.org/10.1007/s00115-012-3645-z
PubMed:View item in PubMed

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