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Aging increases susceptibility to high fat diet-induced metabolic syndrome in C57BL/6 mice: Improvement in glycemic and lipid profile after antioxidant therapy

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Item Type:Article
Title:Aging increases susceptibility to high fat diet-induced metabolic syndrome in C57BL/6 mice: Improvement in glycemic and lipid profile after antioxidant therapy
Creators Name:Nunes-Souza, V. and Cesar-Gomes, C.J. and da Fonseca, L.J.S. and da Silva Guedes, G. and Smaniotto, S. and Rabelo, L.A.
Abstract:Nonalcoholic fatty liver disease (NAFLD) has been considered a novel component of the metabolic syndrome (MetS), with the oxidative stress participating in its progression. This study aimed to evaluate the metabolic profile in young and old mice with MetS, and the effects of apocynin and tempol on glycemic and lipid parameters. Young and old C57BL/6 mice with high fat diet- (HFD-) induced MetS received apocynin and tempol 50 mg·kg(-1)/day in their drinking water for 10 weeks. After HFD, the young group showed elevated fasting glucose, worsened lipid profile in plasma, steatosis, and hepatic lipid peroxidation. Nevertheless, the old group presented significant increase in fasting insulin levels, insulin resistance, plasma and hepatic lipid peroxidation, and pronounced steatosis. The hepatic superoxide dismutase and catalase activity did not differ between the groups. Tempol and apocynin seemed to prevent hepatic lipid deposition in both groups. Furthermore, apocynin improved glucose tolerance and insulin sensitivity in old mice. In summary, old mice are more susceptible to HFD-induced metabolic changes than their young counterparts. Also, the antioxidant therapy improved insulin sensitivity and glucose tolerance, and in addition, apocynin seemed to prevent the HFD-induced hepatic fat deposition, suggesting an important role of oxidative stress in the induction of NAFLD.
Keywords:Acetophenones, Aging, Animal Disease Models, Antioxidants, Blood Glucose, Catalase, Cyclic N-Oxides, Glucose Tolerance Test, High-Fat Diet, Insulin, Lipid Peroxidation, Lipids, Liver, Metabolic Syndrome X, Non-Alcoholic Fatty Liver Disease, Spin Labels, Superoxide Dismutase, Triglycerides, Animals, Mice
Source:Oxidative Medicine and Cellular Longevity
ISSN:1942-0900
Publisher:Hindawi (U.S.A.)
Volume:2016
Page Range:1987960
Date:2016
Official Publication:https://doi.org/10.1155/2016/1987960
PubMed:View item in PubMed

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