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Relaxin treatment in an Ang-II-based transgenic reeclamptic-rat model

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Item Type:Article
Title:Relaxin treatment in an Ang-II-based transgenic reeclamptic-rat model
Creators Name:Haase, N. and Golic, M. and Herse, F. and Rugor, J. and Linz, D. and Solano, M.E. and Müller, D.N. and Dechend, R.
Abstract:Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure. Preeclampsia is a pregnancy disorder, featuring hypertension, proteinuria and placental anomalies. We investigated relaxin in an established transgenic rat model of preeclampsia, where the phenotype is induced by angiotensin (Ang)-II production in mid pregnancy. We gave recombinant relaxin to preeclamtic rats at day 9 of gestation. Hypertension and proteinuria was not ameliorated after relaxin administration. Intrauterine growth retardation of the fetus was unaltered by relaxin. Heart-rate responses and relaxin levels documented drug effects. In this Ang-II-based model of preeclampsia, we could not show a salubrious effect on preeclampsia.
Keywords:Angiotensins, Animal Disease Models, Fetal Growth Retardation, Pre-Eclampsia, Pregnancy, Relaxin, Transgenic Rats, Animals, Rats
Source:PLoS ONE
Publisher:Public Library of Science
Page Range:e0150743
Date:10 March 2016
Official Publication:https://doi.org/10.1371/journal.pone.0150743
PubMed:View item in PubMed

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