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Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

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Item Type:Article
Title:Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
Creators Name:Chuang, S.C. and Boeing, H. and Vollset, S.E. and Midttun, Ø. and Ueland, P.M. and Bueno-de-Mesquita, B. and Lajous, M. and Fagherazzi, G. and Boutron-Ruault, M.C. and Kaaks, R. and Kühn, T. and Pischon, T. and Drogan, D. and Tjønneland, A. and Overvad, K. and Quirós, J.R. and Agudo, A. and Molina-Montes, E. and Dorronsoro, M. and Huerta, J.M. and Barricarte, A. and Khaw, K.T. and Wareham, N.J. and Travis, R.C. and Trichopoulou, A. and Lagiou, P. and Trichopoulos, D. and Masala, G. and Agnoli, C. and Tumino, R. and Mattiello, A. and Peeters, P.H. and Weiderpass, E. and Palmqvist, R. and Ljuslinder, I. and Gunter, M. and Lu, Y. and Cross, A.J. and Riboli, E. and Vineis, P. and Aleksandrova, K.
Abstract:BACKGROUND: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). RESULTS: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). CONCLUSIONS: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
Keywords:Neopterin, Cell-Mediated Immunity, Metabolic Syndrome
Source:Immunity & Ageing
ISSN:1742-4933
Publisher:BioMed Central
Volume:13
Page Range:5
Date:25 February 2016
Official Publication:https://doi.org/10.1186/s12979-016-0059-y
PubMed:View item in PubMed

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