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Elementary immunology: Na(+) as a regulator of immunity

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Item Type:Review
Title:Elementary immunology: Na(+) as a regulator of immunity
Creators Name:Schatz, V. and Neubert, P. and Schröder, A. and Binger, K. and Gebhard, M. and Müller, D.N. and Luft, F.C. and Titze, J. and Jantsch, J.
Abstract:The skin can serve as an interstitial Na(+) reservoir. Local tissue Na(+) accumulation increases with age, inflammation and infection. This increased local Na(+) availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na(+) availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na(+) levels bears broad therapeutic potential: increasing local Na(+) availability may help in treating infections, while lowering tissue Na(+) levels may be used to treat, for example, autoimmune and cardiovascular diseases.
Keywords:Local Na+ Availability, Skin Salt Storage, Macrophages, T Cells, Immune Cell Functions And Activation, Animals, Mice
Source:Pediatric Nephrology
Page Range:201-210
Date:February 2017
Official Publication:https://doi.org/10.1007/s00467-016-3349-x
PubMed:View item in PubMed

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