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| Item Type: | Review |
|---|---|
| Title: | Elementary immunology: Na(+) as a regulator of immunity |
| Creators Name: | Schatz, V. and Neubert, P. and Schröder, A. and Binger, K. and Gebhard, M. and Müller, D.N. and Luft, F.C. and Titze, J. and Jantsch, J. |
| Abstract: | The skin can serve as an interstitial Na(+) reservoir. Local tissue Na(+) accumulation increases with age, inflammation and infection. This increased local Na(+) availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na(+) availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na(+) levels bears broad therapeutic potential: increasing local Na(+) availability may help in treating infections, while lowering tissue Na(+) levels may be used to treat, for example, autoimmune and cardiovascular diseases. |
| Keywords: | Local Na+ Availability, Skin Salt Storage, Macrophages, T Cells, Immune Cell Functions And Activation, Animals, Mice |
| Source: | Pediatric Nephrology |
| ISSN: | 0931-041X |
| Publisher: | Springer |
| Volume: | 32 |
| Number: | 2 |
| Page Range: | 201-210 |
| Date: | February 2017 |
| Official Publication: | https://doi.org/10.1007/s00467-016-3349-x |
| PubMed: | View item in PubMed |
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