Helmholtz Gemeinschaft


Gut microbiota linked to sexual preference and HIV infection

[img] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:Gut microbiota linked to sexual preference and HIV infection
Creators Name:Noguera-Julian, M. and Rocafort, M. and Guillen, Y. and Rivera, J. and Casadella, M. and Nowak, P. and Hildebrand, F. and Zeller, G. and Parera, M. and Bellido, R. and Rodriguez, C. and Carrillo, J. and Mothe, B. and Coll, J. and Bravo, I. and Estany, C. and Herrero, C. and Saz, J. and Sirera, G. and Torrela, A. and Navarro, J. and Crespo, M. and Brander, C. and Negredo, E. and Blanco, J. and Guarner, F. and Calle, M.L. and Bork, P. and Soennerborg, A. and Clotet, B. and Paredes, R.
Abstract:The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. In two independent cohorts of HIV-1-infected subjects and HIV-1-negative controls in Barcelona (n = 156) and Stockholm (n = 84), men who have sex with men (MSM) predominantly belonged to the Prevotella-rich enterotype whereas most non-MSM subjects were enriched in Bacteroides, independently of HIV-1 status, and with only a limited contribution of diet effects. Moreover, MSM had a significantly richer and more diverse fecal microbiota than non-MSM individuals. After stratifying for sexual orientation, there was no solid evidence of an HIV-specific dysbiosis. However, HIV-1 infection remained consistently associated with reduced bacterial richness, the lowest bacterial richness being observed in subjects with a virological-immune discordant response to antiretroviral therapy. Our findings indicate that HIV gut microbiome studies must control for HIV risk factors and suggest interventions on gut bacterial richness as possible novel avenues to improve HIV-1-associated immune dysfunction.
Keywords:HIV-1, Microbiome, Microbiota, 16S rDNA, Prevotella, Bacteroides
Page Range:135-146
Date:March 2016
Official Publication:https://doi.org/10.1016/j.ebiom.2016.01.032
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library