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Energy metabolism in neuronal/glial induction and iPSC-based modeling of brain disorders

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Item Type:Review
Title:Energy metabolism in neuronal/glial induction and iPSC-based modeling of brain disorders
Creators Name:Mlody, B. and Lorenz, C. and Inak, G. and Prigione, A.
Abstract:The metabolic switch associated with the reprogramming of somatic cells to pluripotency has received increasing attention in recent years. However, the impact of mitochondrial and metabolic modulation on stem cell differentiation into neuronal/glial cells and related brain disease modeling still remains to be fully addressed. Here, we seek to focus on this aspect by first addressing brain energy metabolism and its inter-cellular metabolic compartmentalization. We then review the findings related to the mitochondrial and metabolic reconfiguration occurring upon neuronal/glial specification from pluripotent stem cells (PSCs). Finally, we provide an update of the PSC-based models of mitochondria-related brain disorders and discuss the challenges and opportunities that may exist on the road to develop a new era of brain disease modeling and therapy.
Keywords:Mitochondria, Metabolism, Neurons, Glia, Neural Progenitors, Reprogramming, iPSCs, Mitochondrial Disorders
Source:Seminars in Cell & Developmental Biology
ISSN:1084-9521
Publisher:Academic Press (U.K.)
Volume:52
Page Range:102-109
Date:April 2016
Official Publication:https://doi.org/10.1016/j.semcdb.2016.02.018
PubMed:View item in PubMed

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