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Metabolic regulation: Effects of natriuretic peptide interactions

Item Type:Review
Title:Metabolic regulation: Effects of natriuretic peptide interactions
Creators Name:Birkenfeld, A.L. and Boschmann, M. and Jordan, J.
Abstract:In addition to their well-established effects on blood pressure and volume homeostasis, natriuretic peptides have complex effects on carbohydrate and lipid metabolism. In vivo, pharmacological and physiological concentrations of atrial natriuretic pepticles induce lipolysis in a concentration-dependent manner and increase the lipid oxidation rate. The response appears to be mediated through the stimulation of natriuretic peptide receptor-A. More recent studies suggest that natriuretic peptides also affect the production of several adipokines. These mechanisms may be relevant, as natriuretic peptide availability is altered in numerous physiological and pathological conditions, including physical exercise, congestive heart failure and obesity.
Keywords:Atrial Natriuretic Peptide, Carbohydrate, Cardiac Cachexia, Heart Failure, Lipid Oxidation, Lipolysis, Natriuretic Peptides, Obesity
Source:Expert Review of Endocrinology and Metabolism
ISSN:1744-6651
Publisher:Expert Reviews
Volume:2
Number:5
Page Range:607-614
Date:2007
Official Publication:https://doi.org/10.1586/17446651.2.5.607

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