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Apoptosis and cancer therapy

Item Type:Book Section
Title:Apoptosis and cancer therapy
Creators Name:Reimann, M. and Schmitt, C.A.
Abstract:The observation that tumor development frequently is accompanied by apoptotic defects and the meanwhile accepted view that the vast majority of conventional anticancer agents primarily cause DNA damage to subsequently initiate the apoptotic machinery, have led to the conclusions that the capability to undergo apoptosis must contribute to the outcome of cancer therapy and that mutations compromising apoptosis might confer chemoresistance. However, experimental results from cellculture-based systems and conflicting data from the clinic have prompted reasonable doubts about a critical role of apoptosis in cancer therapy. This chapter highlights the technical difficulties in properly assessing the impact of treatment-induced apoptosis, discusses the value of more complex model systems, and underscores the relevance of apoptosis by providing insights from mouse models harboring tumors with genetically defined lesions and clinical observations based on novel proapoptotic compounds.
Keywords:Apoptosis, Chemotherapy, Mouse Models, Resistance, Senescence, Targeted Therapies
Source:Apoptosis, Cell Signaling, and Human Diseases
Title of Book:Apoptosis, Cell Signaling, and Human Diseases
Publisher:Humana Press
Page Range:303-320
Official Publication:https://doi.org/10.1007/978-1-59745-200-7_13

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