Treatment of sleep disorders may improve fatigue in multiple sclerosis

Item Type:	Article
Title:	Treatment of sleep disorders may improve fatigue in multiple sclerosis
Creators Name:	Veauthier, C. and Gaede, G. and Radbruch, H. and Gottschalk, S. and Wernecke, K.D. and Paul, F.
Abstract:	Objective: In a previous polysomnographic cross-sectional study we found a significant relationship between sleep disorders and multiple sclerosis (MS) related fatigue. The purpose of this open follow-up observation was to compare the impact of treatment of sleep disorders on MS related fatigue measured with the Modified Fatigue Impact Scale (MFIS). Methods: Non-randomized follow-up observation: treated versus untreated patients, subgroups according to compliance with sleep medical treatment recommendations (univariate, multivariate analysis, multiple logistic regression). 66 MS patients were followed after polysomnography, 49 patients with relevant sleep disorders and 17 without. Results: Mean MFIS scores decreased from 41.2 to 26.2 (p = 0.025) in patients with good compliance (GC; n = 18), from 42.4 to 32.1 (p = 0.12) in patients with moderate compliance (MC; n = 12), and from 41.6 to 35.5 (p = 0.17) in non-compliant patients (NC; n = 17). Mean MFIS values increased in patients without sleep disorders from 22.9 to 25.4 (NSD; n = 12, p = 0.56). In multiple logistic regression, treatment of sleep disorders predicted decrease of MFIS-values (GC versus NSD odds ratio 13.4; p = 0.015; 95% confidence interval (CI) 1.7–107.2, MC versus NSD odds ratio 13.8; p = 0.028; 95% CI 1.3–143.3). Conclusions: Sleep medical treatment may improve MS related fatigue when patients adhere to treatment recommendations.
Keywords:	Multiple Sclerosis, Fatigue, Polysomnography, Sleep Disorders, Modified Fatigue Impact Scale
Source:	Clinical Neurology and Neurosurgery
ISSN:	0303-8467
Publisher:	Elsevier
Volume:	115
Number:	9
Page Range:	1826-1830
Date:	September 2013
Official Publication:	https://doi.org/10.1016/j.clineuro.2013.05.018
PubMed:	View item in PubMed

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