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Visual evoked potentials in neuromyelitis optica and its spectrum disorders

Item Type:Article
Title:Visual evoked potentials in neuromyelitis optica and its spectrum disorders
Creators Name:Ringelstein, M. and Kleiter, I. and Ayzenberg, I. and Borisow, N. and Paul, F. and Ruprecht, K. and Kraemer, M. and Cohn, E. and Wildemann, B. and Jarius, S. and Hartung, H.P. and Aktas, O. and Albrecht, P.
Abstract:Optic neuritis (ON) is a key feature of neuromyelitis optica (NMO). Recently, NMO patients of predominantly Afro-Brazilian origin were evaluated by visual evoked potentials (VEPs) and showed marked amplitude reductions. Here, we analyzed VEPs in a predominantly Caucasian cohort, consisting of 43 patients with definite NMO, 18 with anti-aquaporin (AQP) 4 antibody-seropositive NMO spectrum disorders and 61 matched healthy controls. We found reduced amplitudes in only 12.3%, prolonged latencies in 41.9% and a lack of response in 14.0% of NMO eyes. Delayed P100 latencies in eyes without prior ON suggested this was a subclinical affection. The data indicate heterogenous patterns in NMO, warranting further investigation.
Keywords:Aquaporin-4 Antibody, P100 Latency, Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorders, Optic Neuritis, Visual Evoked Potential
Source:Multiple Sclerosis Journal
Publisher:Sage Publications
Page Range:617-620
Date:April 2014
Official Publication:https://doi.org/10.1177/1352458513503053
PubMed:View item in PubMed

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