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High spatial resolution cardiovascular magnetic resonance at 7.0 Tesla in patients with hypertrophic cardiomyopathy - first experiences: lesson learned from 7.0 Tesla

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Item Type:Article
Title:High spatial resolution cardiovascular magnetic resonance at 7.0 Tesla in patients with hypertrophic cardiomyopathy - first experiences: lesson learned from 7.0 Tesla
Creators Name:Prothmann, M. and von Knobelsdorff-Brenkenhoff, F. and Töpper, A. and Dieringer, M.A. and Shahid, E. and Graessl, A. and Rieger, J. and Lysiak, D. and Thalhammer, C. and Huelnhagen, T. and Kellman, P. and Niendorf, T. and Schulz-Menger, J.
Abstract:BACKGROUND: Cardiovascular Magnetic Resonance (CMR) provides valuable information in patients with hypertrophic cardiomyopathy (HCM) based on myocardial tissue differentiation and the detection of small morphological details. CMR at 7.0T improves spatial resolution versus today's clinical protocols. This capability is as yet untapped in HCM patients. We aimed to examine the feasibility of CMR at 7.0T in HCM patients and to demonstrate its capability for the visualization of subtle morphological details. METHODS: We screened 131 patients with HCM. 13 patients (9 males, 56 +/-31 years) and 13 healthy age- and gender-matched subjects (9 males, 55 +/-31years) underwent CMR at 7.0T and 3.0T (Siemens, Erlangen, Germany). For the assessment of cardiac function and morphology, 2D CINE imaging was performed (voxel size at 7.0T: (1.4x1.4x2.5) mm3 and (1.4x1.4x4.0) mm3; at 3.0T: (1.8x1.8x6.0) mm3). Late gadolinium enhancement (LGE) was performed at 3.0T for detection of fibrosis. RESULTS: All scans were successful and evaluable. At 3.0T, quantification of the left ventricle (LV) showed similar results in short axis view vs. the biplane approach (LVEDV, LVESV, LVMASS, LVEF) (p = 0.286; p = 0.534; p = 0.155; p = 0.131). The LV-parameters obtained at 7.0T where in accordance with the 3.0T data (pLVEDV = 0.110; pLVESV = 0.091; pLVMASS = 0.131; pLVEF = 0.182). LGE was detectable in 12/13 (92%) of the HCM patients. High spatial resolution CINE imaging at 7.0T revealed hyperintense regions, identifying myocardial crypts in 7/13 (54%) of the HCM patients. All crypts were located in the LGE-positive regions. The crypts were not detectable at 3.0T using a clinical protocol. CONCLUSIONS: CMR at 7.0T is feasible in patients with HCM. High spatial resolution gradient echo 2D CINE imaging at 7.0T allowed the detection of subtle morphological details in regions of extended hypertrophy and LGE.
Keywords:Case-Control Studies, Cine Magnetic Resonance Imaging, Computer-Assisted Image Processing, Echocardiography, Fibrosis, Gadolinium, Healthy Volunteers, Heart Ventricles, Hypertrophic Cardiomyopathy, Prospective Studies
Source:PLoS ONE
ISSN:1932-6203
Publisher:Public Library of Science (U.S.A.)
Volume:11
Number:2
Page Range:e0148066
Date:10 February 2016
Official Publication:https://doi.org/10.1371/journal.pone.0148066
PubMed:View item in PubMed

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