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Autoantibodies to tetraspanins (CD9, CD81 and CD82) in demyelinating diseases

Item Type:Article
Title:Autoantibodies to tetraspanins (CD9, CD81 and CD82) in demyelinating diseases
Creators Name:Miyaji, K. and Paul, F. and Shahrizaila, N. and Umapathi, T. and Yuki, N.
Abstract:Tetraspanin family proteins, CD9, CD81 and CD82 are expressed in the oligodendrocytes and Schwann cells. We investigated autoantibodies to tetraspanin proteins in patients with demyelinating diseases. Sera were collected from 119 multiple sclerosis patients, 19 neuromyelitis optica, 42 acute inflammatory demyelinating polyneuropathy, 23 chronic inflammatory demyelinating polyneuropathy and 13 acute motor axonal neuropathy as well as 55 healthy controls. Few multiple sclerosis and acute inflammatory demyelinating polyneuropathy patients had autoantibodies that were weakly reactive to CD9 or CD81 but the significance is unclear. It is unlikely that these autoantibodies are pathogenic or serve as potential biomarkers in demyelinating diseases.
Keywords:Acute Inflammatory Demyelinating Polyneuropathies, Chronic Inflammatory Demyelinating Polyneuropathies, Multiple Sclerosis, Tetraspanin
Source:Journal of Neuroimmunology
Page Range:78-81
Date:15 February 2016
Official Publication:https://doi.org/10.1016/j.jneuroim.2015.12.012
PubMed:View item in PubMed

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