Helmholtz Gemeinschaft


Personalized cancer therapy considering cytochrome P450 variability

Item Type:Article
Title:Personalized cancer therapy considering cytochrome P450 variability
Creators Name:Preissner, S. and Simmaco, M. and Gentile, G. and Preissner, R.
Abstract:The individual variability of pharmacokinetics is underestimated and few systematic studies exist in this field. In most cases, this leads to unwanted side effects or toxicity. In polychemotherapy, prodrugs (like ifosfamide), which have to be activated by cytochrome P450 enzymes (CYPs), play an important role. If patients are poor metabolizers for these drugs, the therapy will be ineffective. Furthermore, CYPs and transporters can be (over)expressed in target tissues, which is also not examined and considered in clinical routine. Here, we present a body map showing relevant enzymes in some organs and tissues. Finally, a typical case of a Caucasian chemotherapy patient with breast cancer is presented and discussed regarding a personalized cancer therapy considering the single nucleotide polymorphisms found via genotyping.
Keywords:Drug Cocktail Optimization, Personalized Cancer Therapy, Drug Interactions
Source:Advances in Pharmacology
Series Name:Advances in Pharmacology
Title of Book:Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer
Page Range:113-130
Official Publication:https://doi.org/10.1016/bs.apha.2015.03.004
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library