![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
2MB |
![[thumbnail of Supplementary data]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supplementary data)
16MB |
| Item Type: | Article |
|---|---|
| Title: | Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia |
| Creators Name: | Schaefer, M., Oeing, C.U., Rohm, M., Baysal-Temel, E., Lehmann, L.H., Bauer, R., Volz, H.C., Boutros, M., Sohn, D., Sticht, C., Gretz, N., Eichelbaum, K., Werner, T., Hirt, M.N., Eschenhagen, T., Mueller-Decker, K., Strobel, O., Hackert, T., Krijgsveld, J., Katus, H.A., Berriel Diaz, M., Backs, J. and Herzig, S. |
| Abstract: | Objectives: Cancer cachexia affects the majority of tumor patients and significantly contributes to high mortality rates in these subjects. Despite its clinical importance, the identity of tumor-borne signals and their impact on specific peripheral organ systems, particularly the heart, remain mostly unknown. Methods and results: By combining differential colon cancer cell secretome profiling with large-scale cardiomyocyte phenotyping, we identified a signature panel of seven "cachexokines", including Bridging integrator 1, Syntaxin 7, Multiple inositol-polyphosphate phosphatase 1, Glucosidase alpha acid, Chemokine ligand 2, Adamts like 4, and Ataxin-10, which were both sufficient and necessary to trigger cardiac atrophy and aberrant fatty acid metabolism in cardiomyocytes. As a prototypical example, engineered secretion of Ataxin-10 from non-cachexia-inducing cells was sufficient to induce cachexia phenotypes in cardiomyocytes, correlating with elevated Ataxin-10 serum levels in murine and human cancer cachexia models. Conclusions: As Ataxin-10 serum levels were also found to be elevated in human cachectic cancer patients, the identification of Ataxin-10 as part of a cachexokine cocktail now provides a rational approach towards personalized predictive, diagnostic and therapeutic measures in cancer cachexia. |
| Keywords: | Cancer Cachexia, Ataxin-10, Cardiac Dysfunction, Fatty Acid Metabolism, Animals, Mice |
| Source: | Molecular Metabolism |
| ISSN: | 2212-8778 |
| Publisher: | Elsevier |
| Volume: | 5 |
| Number: | 2 |
| Page Range: | 67-78 |
| Date: | February 2016 |
| Additional Information: | Erratum in: Mol Metab 35: 100970. |
| Official Publication: | https://doi.org/10.1016/j.molmet.2015.11.004 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
