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A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

Item Type:Article
Title:A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation
Creators Name:Goerlich, D. and Prehn, S. and Hartmann, E. and Kalies, K.U. and Rapoport, T.A.
Abstract:SEC61p is essential for protein translocation across the endoplasmic reticulum membrane of S. cerevisiae. We have found a mammalian homolog that shows more than 50% sequence identity with the yeast protein. Moreover, several regions of SEC61p have significant similarities with corresponding ones of SecYp of bacteria, indicating a strong evolutionary conservation of the mechanism of protein translocation. Mammalian Sec61p, like the yeast protein, is located in the immediate vicinity of nascent polypeptides during their membrane passage. It is tightly associated with membrane-bound ribosomes, suggesting that the nascent chain passes directly from the ribosome into a protein-conducting channel. These results define Sec61p as a ubiquitous key component of the protein translocation apparatus.
Keywords:Amino Acid Sequence, Amino Acid Sequence Homology, Bacterial Proteins, Base Sequence, Biological Transport, Consensus Sequence, Endoplasmic Reticulum, Escherichia Coli Proteins, Fungal Proteins, Membrane Proteins, Molecular Sequence Data, Ribosomes, Animals, Dogs
Source:Cell
ISSN:0092-8674
Publisher:Cell Press (U.S.A.)
Volume:71
Number:3
Page Range:489-503
Date:30 October 1992
Official Publication:https://doi.org/10.1016/0092-8674(92)90517-G
PubMed:View item in PubMed

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