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Serotonin attenuates feedback excitation onto O-LM interneurons

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Item Type:Article
Title:Serotonin attenuates feedback excitation onto O-LM interneurons
Creators Name:Böhm, C. and Pangalos, M. and Schmitz, D. and Winterer, J.
Abstract:The serotonergic system is a subcortical neuromodulatory center that controls cortical information processing in a state-dependent manner. In the hippocampus, serotonin (5-HT) is released by ascending serotonergic fibers from the midbrain raphe nuclei, thereby mediating numerous modulatory functions on various neuronal subtypes. Here, we focus on the neuromodulatory effects of 5-HT on GABAergic inhibitory oriens lacunosum-moleculare (O-LM) cells in the hippocampal area CA1 of the rat. These interneurons are thought to receive primarily local excitatory input and are, via their axonal projections to stratum lacunosum-moleculare, ideally suited to control entorhinal cortex input. We show that 5-HT reduces excitatory glutamatergic transmission onto O-LM interneurons. By means of paired recordings from synaptically connected CA1 pyramidal cells and O-LM interneurons we reveal that this synapse is modulated by 5-HT. Furthermore, we demonstrate that the reduction of glutamatergic transmission by serotonin is likely to be mediated via a decrease of calcium influx into presynaptic terminals of CA1 pyramidal cells. This modulation of excitatory synaptic transmission onto O-LM interneurons by 5-HT might be a mechanism to vary the activation of O-LM interneurons during ongoing network activity and serve as a brain state-dependent switch gating the efficiency of entorhinal cortex input to CA1 pyramidal neurons.
Keywords:5-HT, CA1, Paired Recordings, Presynaptic Neuromodulation, Animals, Rats
Source:Cerebral Cortex
ISSN:1047-3211
Publisher:Oxford Univ Press (U.S.A.)
Volume:25
Number:11
Page Range:4572-4583
Date:November 2015
Official Publication:https://doi.org/10.1093/cercor/bhv098
PubMed:View item in PubMed

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