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Neurogenic amplification of immune complex inflammation

Item Type:Article
Title:Neurogenic amplification of immune complex inflammation
Creators Name:Bozic, C.R. and Lu, B. and Höpken, U.E. and Gerard, C. and Gerard, N.P.
Abstract:The formation of intrapulmonary immune complexes in mice generates a vigorous inflammatory response characterized by microvascular permeability and polymorphonuclear neutrophil influx. Gene-targeted disruption of the substance P receptor (NK-1R) protected the lung from immune complex injury, as did disruption of the C5a anaphylatoxin receptor. Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung.
Keywords:Anaphylatoxin C5a Receptor, Antigen-Antibody Complex, Bronchoalveolar Lavage Fluid, Capillary Permeability, CD Antigens, Complement C5a, Complement Receptors, Gene Targeting, Immune Complex Diseases, Inbred C57BL Mice, Inflammation, Lung, Lung Diseases, Neurokinin-1 Receptors, Neutrophils, Substance P, Tumor Necrosis Factor-{alpha}, Animals, Mice
Publisher:American Association for the Advancement of Science
Page Range:1722-1725
Date:20 September 1996
Official Publication:https://doi.org/10.1126/science.273.5282.1722
PubMed:View item in PubMed

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