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Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor

Item Type:Article
Title:Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor
Creators Name:Hoepken, U.E. and Lu, B. and Gerard, N.P. and Gerard, C.
Abstract:We recently demonstrated that gene-targeted disruption of the C5a anaphylatoxin receptor prevented lung injury in immune complex-mediated inflammation. In this study, we compare the effect of C5aR deficiency in immune complex-induced inflammation in the peritoneal cavity and skin with the results derived from our immune complex alveolitis model. C5aR- deficient mice exhibit decreased migration of neutrophils and decreased levels of TNF-{alpha} and interleukin 6 in the peritoneal reverse passive Arthus reaction compared to their wild-type littermates. In the reverse passive Arthus reaction in the skin the C5aR was also required for the full expression of neutrophil influx and edema formation; C5aR-deficient mice showed reduced neutrophil migration and microvascular permeability changes. In contrast to our studies in immune complex-induced lung inflammation, C5aR deficiency does not completely prevent injury in the peritoneal cavity and skin. These data indicate a dominant role for the C5aR and its ligand in the reverse passive Arthus reaction in the lung and a synergistic role together with other inflammatory mediators in immune complex-mediated peritonitis and skin injury.
Keywords:Anaphylatoxin C5a Receptor, Antibodies, Arthus Reaction, Capillary Permeability, CD Antigens, Cell Count, Complement Receptors, Complement System Proteins, Edema, Fc Receptors, Gene Targeting, Immune Complex Diseases, Immunoglobulin G, Inflammation, Interleukin-6, Knockout Mice, Lung, Neutrophils, Ovalbumin, Peritonitis, Peroxidase, Tumor Necrosis Factor-{alpha}, Animals, Mice
Source:Journal of Experimental Medicine
ISSN:0022-1007
Publisher:Rockefeller University Press (U.S.A.)
Volume:186
Number:5
Page Range:749-756
Date:29 August 1997
Official Publication:https://doi.org/10.1084/jem.186.5.749
PubMed:View item in PubMed

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