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The C5a chemoattractant receptor mediates mucosal defence to infection

Item Type:Article
Title:The C5a chemoattractant receptor mediates mucosal defence to infection
Creators Name:Hoepken, U.E. and Lu, B. and Gerard, N.P. and Gerard, C.
Abstract:A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages. This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphyla-toxins(1-3). The apparent redundancy of these receptors suggests that they have an important underlying role in host defence. To isolate the contribution of particular molecules, we disrupted a gene that encodes a single chemoattractant receptor. Here we show that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermates, were unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite a marked increase in neutrophil influx, and succumbed to pneumonia. These C5a-receptor-deficient mice challenged with sublethal inocula of Pseudomonas become superinfected with secondary bacterial strains. We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung.
Keywords:Bacterial Pneumonia, Complement C5a, Innate Immunity, Knockout Mice, Leukocyte Chemotaxis, Lung, Mucosal Immunity, Neutrophils, Peritoneum, Phagocytosis, Pseudomonas Infections, Animals, Mice
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:383
Number:6595
Page Range:86-89
Date:5 September 1996
Official Publication:https://doi.org/10.1038/383086a0
PubMed:View item in PubMed

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