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Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases

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Item Type:Review
Title:Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases
Creators Name:Schmidt, V. and Willnow, T.E.
Abstract:VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances. In this review, we discuss current findings that uncovered some of the molecular mechanisms whereby sorting receptors, such as SORLA, sortilin, and SORCS1 control homeostasis in cardiovascular and metabolic tissues, and how they promote hypercholesterolemia, atherosclerosis, obesity, and diabetes, when being altered.
Keywords:Protein Sorting, VPS10P Domain Receptors, Lipoprotein Receptors, GWAS, Risk Genes, Cholesterol Metabolism, Mouse Models
Source:Atherosclerosis
ISSN:0021-9150
Publisher:Elsevier (Ireland)
Volume:245
Page Range:194-199
Date:February 2016
Official Publication:https://doi.org/10.1016/j.atherosclerosis.2015.11.027
PubMed:View item in PubMed

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