The role of microglia and macrophages in glioma maintenance and progression
Item Type: | Review |
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Title: | The role of microglia and macrophages in glioma maintenance and progression |
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Creators Name: | Hambardzumyan, D. and Gutmann, D.H. and Kettenmann, H. |
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Abstract: | There is a growing recognition that gliomas are complex tumors composed of neoplastic and non-neoplastic cells, which each individually contribute to cancer formation, progression and response to treatment. The majority of the non-neoplastic cells are tumor-associated macrophages (TAMs), either of peripheral origin or representing brain-intrinsic microglia, that create a supportive stroma for neoplastic cell expansion and invasion. TAMs are recruited to the glioma environment, have immune functions, and can release a wide array of growth factors and cytokines in response to those factors produced by cancer cells. In this manner, TAMs facilitate tumor proliferation, survival and migration. Through such iterative interactions, a unique tumor ecosystem is established, which offers new opportunities for therapeutic targeting. |
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Keywords: | Central Nervous System Neoplasms, Disease Progression, Glioma, Macrophages, Microglia, Animals |
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Source: | Nature Neuroscience |
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ISSN: | 1097-6256 |
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Publisher: | Nature Publishing Group |
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Volume: | 19 |
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Number: | 1 |
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Page Range: | 20-27 |
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Date: | January 2016 |
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Official Publication: | https://doi.org/10.1038/nn.4185 |
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PubMed: | View item in PubMed |
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