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The role of microglia and macrophages in glioma maintenance and progression

Official URL:https://doi.org/10.1038/nn.4185
PubMed:View item in PubMed
Creators Name:Hambardzumyan, D. and Gutmann, D.H. and Kettenmann, H.
Journal Title:Nature Neuroscience
Journal Abbreviation:Nat Neurosci
Page Range:20-27
Date:January 2016
Keywords:Central Nervous System Neoplasms, Disease Progression, Glioma, Macrophages, Microglia, Animals
Abstract:There is a growing recognition that gliomas are complex tumors composed of neoplastic and non-neoplastic cells, which each individually contribute to cancer formation, progression and response to treatment. The majority of the non-neoplastic cells are tumor-associated macrophages (TAMs), either of peripheral origin or representing brain-intrinsic microglia, that create a supportive stroma for neoplastic cell expansion and invasion. TAMs are recruited to the glioma environment, have immune functions, and can release a wide array of growth factors and cytokines in response to those factors produced by cancer cells. In this manner, TAMs facilitate tumor proliferation, survival and migration. Through such iterative interactions, a unique tumor ecosystem is established, which offers new opportunities for therapeutic targeting.
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Review

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