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Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson's disease

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Item Type:Article
Title:Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson's disease
Creators Name:Lipp, A. and Trbojevic, R. and Paul, F. and Fehlner, A. and Hirsch, S. and Scheel, M. and Noack, C. and Braun, J. and Sack, I.
Abstract:Detection and discrimination of neurodegenerative Parkinson syndromes are challenging clinical tasks and the use of standard T1- and T2-weighted cerebral magnetic resonance (MR) imaging is limited to exclude symptomatic Parkinsonism. We used a quantitative structural MR-based technique, MR-elastography (MRE), to assess viscoelastic properties of the brain, providing insights into altered tissue architecture in neurodegenerative diseases on a macroscopic level. We measured single-slice multifrequency MRE (MMRE) and three-dimensional MRE (3DMRE) in two neurodegenerative disorders with overlapping clinical presentation but different neuropathology — progressive supranuclear palsy (PSP: N = 16) and idiopathic Parkinson's disease (PD: N = 18) as well as in controls (N = 18). In PSP, both MMRE (Δμ = − 28.8%, Δα = − 4.9%) and 3DMRE (Δ|G*|: − 10.6%, Δφ: − 34.6%) were significantly reduced compared to controls, with a pronounced reduction within the lentiform nucleus (Δμ = − 34.6%, Δα = − 8.1%; Δ|G*|: − 7.8%, Δφ: − 44.8%). MRE in PD showed a comparable pattern, but overall reduction in brain elasticity was less severe reaching significance only in the lentiform nucleus (Δμ n.s., Δα = − 7.4%; Δ|G*|: − 6.9%, Δφ: n.s.). Beyond that, patients showed a close negative correlation between MRE constants and clinical severity. Our data indicate that brain viscoelasticity in PSP and PD is differently affected by the underlying neurodegeneration; whereas in PSP all MRE constants are reduced and changes in brain softness (reduced μ and |G*|) predominate those of viscosity (α and φ) in PD.
Keywords:MR-Elastography, MRE, Elasticity, Viscosity, Parkinson Disease, Progressive Supranuclear Palsy
Source:NeuroImage: Clinical
Page Range:381-387
Date:20 September 2013
Official Publication:https://doi.org/10.1016/j.nicl.2013.09.006
PubMed:View item in PubMed

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