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Assessment of renal hemodynamics and oxygenation by simultaneous magnetic resonance imaging (MRI) and quantitative invasive physiological measurements

Item Type:Article
Title:Assessment of renal hemodynamics and oxygenation by simultaneous magnetic resonance imaging (MRI) and quantitative invasive physiological measurements
Creators Name:Cantow, K. and Arakelyan, K. and Seeliger, E. and Niendorf, T. and Pohlmann, A.
Abstract:In vivo assessment of renal perfusion and oxygenation under (patho)physiological conditions by means of noninvasive diagnostic imaging is conceptually appealing. Blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) and quantitative parametric mapping of the magnetic resonance (MR) relaxation times T 2* and T 2 are thought to provide surrogates of renal tissue oxygenation. The validity and efficacy of this technique for quantitative characterization of local tissue oxygenation and its changes under different functional conditions have not been systematically examined yet and remain to be established. For this purpose, the development of an integrative multimodality approaches is essential. Here we describe an integrated hybrid approach (MR-PHYSIOL) that combines established quantitative physiological measurements with T 2* (T 2) mapping and MR-based kidney size measurements. Standardized reversible (patho)physiologically relevant interventions, such as brief periods of aortic occlusion, hypoxia, and hyperoxia, are used for detailing the relation between the MR-PHYSIOL parameters, in particular between renal T 2* and tissue oxygenation.
Keywords:Magnetic Resonance Imaging (MRI), Blood Oxygenation Level Dependent (BOLD), Oxygenation, Perfusion, Hypoxia, Hyperoxia, Animals, Rats
Source:Methods in Molecular Biology
ISSN:1064-3745
Publisher:Springer / Humana Press (U.S.A.)
Volume:1397
Page Range:129-154
Date:17 December 2015
Official Publication:https://doi.org/10.1007/978-1-4939-3353-2_11
PubMed:View item in PubMed

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