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Magnetic resonance imaging (MRI) analysis of ischemia/reperfusion in experimental acute renal injury

Item Type:Article
Title:Magnetic resonance imaging (MRI) analysis of ischemia/reperfusion in experimental acute renal injury
Creators Name:Pohlmann, A. and Arakelyan, K. and Seeliger, E. and Niendorf, T.
Abstract:Imbalance between renal oxygen delivery and demand in the first hours after reperfusion is suggested to be decisive in the pathophysiological chain of events leading to ischemia-induced acute kidney injury. Here we describe blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) for continuous monitoring of the deoxyhemoglobin-sensitive MR parameter T 2* in the renal cortex, outer medulla, and inner medulla of rats throughout renal ischemia/reperfusion (I/R). Changes during I/R are benchmarked against the effects of variations in the fraction of inspired oxygen (hypoxia, hyperoxia). This method may be useful for investigating renal blood oxygenation of rats in vivo under various experimental (patho)physiological conditions.
Keywords:Magnetic Resonance Imaging (MRI), Blood Oxygenation Level Dependent (BOLD), Oxygenation, Ischemia, Hypoxia, Hyperoxia, Animals, Rats
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Kidney research : experimental protocols
ISSN:1064-3745
ISBN:978-1-4939-3351-8
Publisher:Springer / Humana Press (U.S.A.)
Volume:1397
Page Range:113-127
Number of Pages:292
Date:17 December 2015
Official Publication:https://doi.org/10.1007/978-1-4939-3353-2_10
PubMed:View item in PubMed

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