Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Significant reduction in helicobacter pylori load in humans with non-viable lactobacillus reuteri DSM17648: A pilot study

[thumbnail of Original article]
Preview
PDF (Original article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB

Item Type:Article
Title:Significant reduction in helicobacter pylori load in humans with non-viable lactobacillus reuteri DSM17648: A pilot study
Creators Name:Holz, C., Busjahn, A., Mehling, H., Arya, S., Boettner, M., Habibi, H. and Lang, C.
Abstract:Reducing the amount of Helicobacter pylori in the stomach by selective bacterial-bacterial cell interaction was sought as an effective and novel method for combating the stomach pathogen. Lactobacillus reuteri DSM17648 was identified as a highly specific binding antagonist to H. pylori among more than 700 wild-type strains of Lactobacillus species. Applying a stringent screening procedure, the strain DSM17648 was identified as selective binder to H. pylori cells under in vivo gastric conditions. The strain DSM17648 co-aggregates the pathogen in vivo and in vitro. The specific co-aggregation occurs between Lact. reuteri DSM17648 and different H. pylori strains and serotypes, as well as H. heilmannii, but not with Campylobacter jejuni or other commensal oral and intestinal bacteria. Lact. reuteri DSM17648 was shown in a proof-of-concept single-blinded, randomized, placebo-controlled pilot study to significantly reduce the load of H. pylori in healthy yet infected adults. Reducing the amount of H. pylori in the stomach by selective bacterial-bacterial cell interaction might be an effective and novel method for combating the stomach pathogen. Lact. reuteri DSM17648 might prove useful as an adhesion blocker in antibiotic-free H. pylori therapies.
Keywords:Helicobacter Pylori, Lactobacillus Reuteri, Selective Binding, Co-Aggregation, Urea Breath Test, Antibiotic-Free Therapy
Source:Probiotics and Antimicrobial Proteins
ISSN:1867-1306
Volume:7
Number:2
Page Range:91-100
Date:June 2015
Official Publication:https://doi.org/10.1007/s12602-014-9181-3
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library