Monitoring hemodynamics and oxygenation of the kidney in rats by a combined near-infrared spectroscopy and invasive probe approach

Item Type:	Conference or Workshop Item
Title:	Monitoring hemodynamics and oxygenation of the kidney in rats by a combined near-infrared spectroscopy and invasive probe approach
Creators Name:	Grosenick, D. and Cantow, K. and Arakelyan, K. and Wabnitz, H. and Flemming, B. and Skalweit, A. and Ladwig, M. and Macdonald, R. and Niendorf, T. and Seeliger, E.
Abstract:	We have developed a hybrid approach to investigate the dynamics of perfusion and oxygenation in the kidney of rats under pathophysiologically relevant conditions. Our approach combines near-infrared spectroscopy to quantify hemoglobin concentration and oxygen saturation in the renal cortex, and an invasive probe method for measuring total renal blood flow by an ultrasonic probe, perfusion by laser-Doppler fluxmetry, and tissue oxygen tension via fluorescence quenching. Hemoglobin concentration and oxygen saturation were determined from experimental data by a Monte Carlo model. The hybrid approach was applied to investigate and compare temporal changes during several types of interventions such as arterial and venous occlusions, as well as hyperoxia, hypoxia and hypercapnia induced by different mixtures of the inspired gas. The approach was also applied to study the effects of the x-ray contrast medium iodixanol on the kidney.
Keywords:	Animals, Rats
Source:	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN:	0277-786X
Publisher:	SPIE
Volume:	9538
Page Range:	95380L
Date:	16 July 2015
Official Publication:	https://doi.org/10.1117/12.2183417

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