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Dynamic endothelial cell rearrangements drive developmental vessel regression

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Item Type:Article
Title:Dynamic endothelial cell rearrangements drive developmental vessel regression
Creators Name:Franco, C.A. and Jones, M.L. and Bernabeu, M.O. and Geudens, I. and Mathivet, T. and Rosa, A. and Lopes, F.M. and Lima, A.P. and Ragab, A. and Collins, R.T. and Phng, L.K. and Coveney, P.V. and Gerhardt, H.
Abstract:Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomosis in reverse. Establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network, we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments.
Keywords:Biological Models, Blood Vessels, Cell Polarity, Vascular Endothelium, Animals
Source:PLoS Biology
Publisher:Public Library of Science
Page Range:e1002125
Date:17 April 2015
Additional Information:Erratum in: PLoS Biol 13(5): e1002163.
Official Publication:https://doi.org/10.1371/journal.pbio.1002125
PubMed:View item in PubMed

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