Helmholtz Gemeinschaft


Quantitative, organ-specific interscanner and intrascanner variability for 3 T whole-body magnetic resonance imaging in a multicenter, multivendor study

Item Type:Article
Title:Quantitative, organ-specific interscanner and intrascanner variability for 3 T whole-body magnetic resonance imaging in a multicenter, multivendor study
Creators Name:Schlett, C.L. and Hendel, T. and Hirsch, J. and Weckbach, S. and Caspers, S. and Schulz-Menger, J. and Ittermann, T. and von Knobelsdorff-Brenkenhoff, F. and Ladd, S.C. and Moebus, S. and Stroszczynski, C. and Fischer, B. and Leitzmann, M. and Kuhl, C. and Pessler, F. and Hartung, D. and Kemmling, Y. and Hetterich, H. and Amunts, K. and Guenther, M. and Wacker, F. and Rummeny, E. and Kauczor, H.U. and Forsting, M. and Völzke, H. and Hosten, N. and Reiser, M.F. and Bamberg, F.
Abstract:INTRODUCTION: Whole-body magnetic resonance (MR) imaging is increasingly implemented in population-based cohorts and clinical settings. However, to quantify the variability introduced by the different scanners is essential to make conclusions about clinical and biological data, and relevant for internal/external validity. Thus, we determined the interscanner and intrascanner variability of different 3 T MR scanners for whole-body imaging. METHODS: Thirty volunteers were enrolled to undergo multicentric, interscanner as well intrascanner imaging as part of the German National Cohort pilot studies. A comprehensive whole-body MR protocol was installed at 9 sites including 7 different MR scanner models by all 4 major vendors. A set of quantitative, organ-specific measures (n = 20; eg, volume of brain's gray/white matter, pulmonary trunk diameter, vertebral body height) were obtained in blinded fashion. Reproducibility was determined using mean weighted relative differences and intraclass correlation coefficients. RESULTS: All participants (44 +/- 14 years, 50% female) successfully completed the imaging protocol except for two because of technical issues. Mean scan time was 2 hours and 32 minutes and differed significantly across scanners (range, 1 hour 59 minutes to 3 hours 12 minutes). A higher reproducibility of obtained measurements was observed for intrascanner than for interscanner comparisons (intraclass correlation coefficients, 0.80 +/- 0.17 vs 0.60 +/- 0.31, P = 0.005, respectively). In the interscanner comparison, mean relative difference ranged from 1.0% to 53.2%. Conversely, in the intrascanner comparison, mean relative difference ranged from 0.1% to 15.6%. There were no statistical differences for intrascanner and interscanner reproducibility between the different organ foci (all P >/= 0.24). CONCLUSIONS: While whole-body MR imaging-derived, organ-specific parameters are generally associated with good to excellent reproducibility, smaller differences are obtained when using identical MR scanner models by a single vendor.
Keywords:Whole-Body Imaging, Population-Based Imaging, German National Cohort, Reproducibility, Variability, 3 T Magnetic Resonance Tomography
Source:Investigative Radiology
Publisher:Lippincott Williams & Wilkins
Page Range:255-265
Date:April 2016
Official Publication:https://doi.org/10.1097/RLI.0000000000000237
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library