Second-line treatment in pancreatic cancer patients: Who profits? Results from the CONKO study group

Item Type:	Article
Title:	Second-line treatment in pancreatic cancer patients: Who profits? Results from the CONKO study group
Creators Name:	Sinn, M. and Daelken, L. and Striefler, J.K. and Bischoff, S. and Schweitzer, N. and Pelzer, U. and Doerken, B. and Riess, H. and Stieler, J.M.
Abstract:	OBJECTIVES: With increasing numbers of therapeutic options in inoperable pancreatic cancer (PAC), patients tend to receive more than just a first line (FL) therapy. METHODS: All patients who started FL for PAC at our institution (1997-2012) were retrospectively studied to identify patient's and treatment characteristics. Significant parameters in regard to second-line (SL) related survival were looked for as the basis for a prognostic model. This score was validated in a patient cohort from the CONKO-003 study. RESULTS: Two hundred eighty of 521 (53.7%) patients received SL therapy, median overall survival (OS) from the beginning of SL (OS2) was 5.1 months. Significant more SL patients had undergone surgery, a higher Karnofsky performance state (KPS) and a duration of FL longer than 4 months.Prognostic factors impacting OS2 were KPS, carbohydrate antigen 19-9 levels at start of SL and the duration of FL. These 3 factors establish a prognostic score-validated in CONKO-003-for SL patients with 3 subgroups: "good" (median OS2, 9.3 months), "intermediate" (median OS2, 7.1 months), "poor" prognosis (median OS2, 3.8 months; P < 0.001). CONCLUSIONS: Among patients with PAC, more than 50% receive SL therapy. Our prognostic model identifies 3 subgroups and can identify patients with a maximum benefit of SL therapy.
Keywords:	Pancreatic Cancer, Second-Line Therapy, Chemotherapy, Prognostic Score, CONKO-003
Source:	Pancreas
ISSN:	0885-3177
Publisher:	Lippincott Williams & Wilkins
Volume:	45
Number:	4
Page Range:	601-605
Date:	April 2016
Official Publication:	https://doi.org/10.1097/MPA.0000000000000533
PubMed:	View item in PubMed

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