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Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions

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Item Type:Editorial
Title:Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions
Creators Name:Glahs, A. and Zinzen, R.P.
Abstract:Cell fate decisions require the deployment of distinct transcriptional programmes—how this is controlled and orchestrated is a key question from basic developmental biology to regenerative medicine. In this issue of The EMBO Journal, Pataskar and Jung et al (Pataskar et al, 2015) demonstrate how the transcription factor NeuroD1 acts genome‐wide to elicit a specific neurogenic programme, including differentiation and migration. Much of that activity is due to NeuroD1 acting as a pioneer factor. NeuroD1 is able to bind its targets within repressive chromatin and can induce a more open chromatin state amenable to cell type‐specific regulation.
Keywords:Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Chromatin, Developmental Gene Expression Regulation, Neurons, Transcription Factors, Animals
Source:EMBO Journal
ISSN:0261-4189
Publisher:EMBO Press
Volume:35
Number:1
Page Range:1-3
Date:4 January 2016
Official Publication:https://doi.org/10.15252/embj.201593324
PubMed:View item in PubMed

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