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| Item Type: | Article |
|---|---|
| Title: | Meta-analysis identifies seven susceptibility loci involved in the atopic march |
| Creators Name: | Marenholz, I. and Esparza-Gordillo, J. and Rüschendorf, F. and Bauerfeind, A. and Strachan, D.P. and Spycher, B.D. and Baurecht, H. and Margaritte-Jeannin, P. and Sääf, A. and Kerkhof, M. and Ege, M. and Baltic, S. and Matheson, M.C. and Li, J. and Michel, S. and Ang, W.Q. and McArdle, W. and Arnold, A. and Homuth, G. and Demenais, F. and Bouzigon, E. and Söderhäll, C. and Pershagen, G. and de Jongste, J.C. and Postma, D.S. and Braun-Fahrlaender, C. and Horak, E. and Ogorodova, L.M. and Puzyrev, V.P. and Bragina, E.Y. and Hudson, T.J. and Morin, C. and Duffy, D.L. and Marks, G.B. and Robertson, C.F. and Montgomery, G.W. and Musk, B. and Thompson, P.J. and Martin, N.G. and James, A. and Sleiman, P. and Toskala, E. and Rodriguez, E. and Fölster-Holst, R. and Franke, A. and Lieb, W. and Gieger, C. and Heinzmann, A. and Rietschel, E. and Keil, T. and Cichon, S. and Nöthen, M.M. and Pennell, C.E. and Sly, P.D. and Schmidt, C.O. and Matanovic, A. and Schneider, V. and Heinig, M. and Hübner, N. and Holt, P.G. and Lau, S. and Kabesch, M. and Weidinger, S. and Hakonarson, H. and Ferreira, M.A.R. and Laprise, C. and Freidin, M.B. and Genuneit, J. and Koppelman, G.H. and Melén, E. and Dizier, M.H. and Henderson, A.J. and Lee, Y.A. |
| Abstract: | Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema. |
| Keywords: | Biological Sciences, Genetics |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 6 |
| Page Range: | 8804 |
| Date: | 6 November 2015 |
| Official Publication: | https://doi.org/10.1038/ncomms9804 |
| PubMed: | View item in PubMed |
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