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| Item Type: | Article |
|---|---|
| Title: | (23)Na magnetic resonance imaging of the lower leg of acute heart failure patients during diuretic treatment |
| Creators Name: | Hammon, M. and Grossmann, S. and Linz, P. and Kopp, C. and Dahlmann, A. and Garlichs, C. and Janka, R. and Cavallaro, A. and Luft, F.C. and Uder, M. and Titze, J. |
| Abstract: | OBJECTIVE: Na+ can be stored in muscle and skin without commensurate water accumulation. The aim of this study was to assess Na+ and H2O in muscle and skin with MRI in acute heart failure patients before and after diuretic treatment and in a healthy cohort. METHODS: Nine patients (mean age 78 years; range 58-87) and nine age and gender-matched controls were studied. They underwent 23Na/1H-MRI at the calf with a custom-made knee coil. Patients were studied before and after diuretic therapy. 23Na-MRI gray-scale measurements of Na+-phantoms served to quantify Na+-concentrations. A fat-suppressed inversion recovery sequence was used to quantify H2O content. RESULTS: Plasma Na+-levels did not change during therapy. Mean Na+-concentrations in muscle and skin decreased after furosemide therapy (before therapy: 30.7+/-6.4 and 43.5+/-14.5 mmol/L; after therapy: 24.2+/-6.1 and 32.2+/-12.0 mmol/L; p<0.05 and p<0.01). Water content measurements did not differ significantly before and after furosemide therapy in muscle (p = 0.17) and only tended to be reduced in skin (p = 0.06). Na+-concentrations in calf muscle and skin of patients before and after diuretic therapy were significantly higher than in healthy subjects (18.3+/-2.5 and 21.1+/-2.3 mmol/L). CONCLUSIONS: 23Na-MRI shows accumulation of Na+ in muscle and skin in patients with acute heart failure. Diuretic treatment can mobilize this Na+-deposition; however, contrary to expectations, water and Na+-mobilization are poorly correlated. |
| Keywords: | Case-Control Studies, Diuretics, Heart Failure, Leg, Magnetic Resonance Imaging, Prospective Studies, Skeletal Muscle, Skin, Sodium, Water |
| Source: | PLoS ONE |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Volume: | 10 |
| Number: | 10 |
| Page Range: | e0141336 |
| Date: | 26 October 2015 |
| Official Publication: | https://doi.org/10.1371/journal.pone.0141336 |
| PubMed: | View item in PubMed |
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