The latent dementia phenotype δ is associated with cerebrospinal fluid biomarkers of Alzheimer's disease and predicts conversion to dementia in subjects with mild cognitive impairment

Item Type:	Article
Title:	The latent dementia phenotype δ is associated with cerebrospinal fluid biomarkers of Alzheimer's disease and predicts conversion to dementia in subjects with mild cognitive impairment
Creators Name:	Koppara, A. and Wolfsgruber, S. and Kleineidam, L. and Schmidtke, K. and Froelich, L. and Kurz, A. and Schulz, S. and Hampel, H. and Heuser, I. and Peters, O. and Reischies, F.M. and Jahn, H. and Luckhaus, C. and Huell, M. and Gertz, H.J. and Schroeder, J. and Pantel, J. and Rienhoff, O. and Ruether, E. and Henn, F. and Wiltfang, J. and Maier, W. and Jessen, F. and Kornhuber, J. and Wagner, M.
Abstract:	BACKGROUND: The recently proposed latent variable delta is a new tool for dementia case finding. It is built in a structural equation modeling framework of cognitive and functional data and constitutes a novel endophenotype for Alzheimer's disease (AD) research and clinical trials. OBJECTIVE: To investigate the association of delta with AD biomarkers and to compare the prediction of delta with established scales for conversion to dementia in patients with mild cognitive impairment (MCI). METHODS: Using data from a multicenter memory clinic study, we examined the external associations of the latent variable delta and compared delta with well-established cognitive and functional scales and cognitive-functional composite scores. For that purpose, logistic regressions with cerebrospinal fluid (CSF) biomarkers and conversion to dementia as dependent variables were performed with the investigated scores. The models were tested for significant differences. RESULTS: In patients with MCI, delta based on a broad range of cognitive scales (including the ADAS-cog, the MMSE, and the CERAD neuropsychological battery) predicted an abnormal CSF Abeta 42/tau ratio indicative of AD (n = 340, AUC = 0.78, p < 0.001), and predicted incident dementia within 1-3 years of follow-up (n = 525, AUC = 0.84, p < 0.001). These associations were generally stronger than for any other scale or cognitive-functional composite examined. Homologs of delta based on reduced test batteries yielded somewhat lower effects. CONCLUSION: These findings support the interpretation of delta as a construct capturing the disease-related "essence" of cognitive and functional impairments in patients with MCI and dementia, and suggest that delta might become an analytical tool for dementia research.
Keywords:	CSF AD Biomarker Signature, Delta Model, Incident Dementia
Source:	Journal of Alzheimer's Disease
ISSN:	1387-2877
Publisher:	IOS Press
Volume:	49
Number:	2
Page Range:	547-560
Date:	17 October 2015
Official Publication:	https://doi.org/10.3233/JAD-150257
PubMed:	View item in PubMed

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