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Identifying RBP targets with RIP-seq

Item Type:Article
Title:Identifying RBP targets with RIP-seq
Creators Name:Wessels, H.H. and Hirsekorn, A. and Ohler, U. and Mukherjee, N.
Abstract:Throughout their lifetime RNA molecules interact with a variety of RNA-binding proteins (RBPs). RBPs control gene expression by regulating splicing, polyadenylation, editing, transport, stability, and translation of RNA. There are ~1500 RBPs encoded by the human genome and recent studies have detected ~1100 proteins directly interacting with polyadenylated RNA. Identifying the RNAs bound by RBPs will continue to provide important insights into the regulation of gene expression.
Keywords:Ribonucleoprotein, Immunoprecipitation, RNA-Binding Protein, RNA-Seq
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Post-Transcriptional Gene Regulation
ISSN:1064-3745
ISBN:978-1-4939-3066-1
Publisher:Springer / Humana Press (U.S.A.)
Volume:1358
Page Range:141-152
Number of Pages:353
Date:2016
Official Publication:https://doi.org/10.1007/978-1-4939-3067-8_9
PubMed:View item in PubMed

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