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Ultrahigh-field MPRAGE magnetic resonance angiography at 7.0 T in patients with cerebrovascular disease

Item Type:Article
Title:Ultrahigh-field MPRAGE magnetic resonance angiography at 7.0 T in patients with cerebrovascular disease
Creators Name:Madai, V.I. and von Samson-Himmelstjerna, F.C. and Sandow, N. and Weiler, F. and Bauer, M. and Vajkoczy, P. and Günther, M. and Dusek, P. and von Gottberg, P. and Niendorf, T. and Wuerfel, J. and Sobesky, J.
Abstract:Objectives: Time-of-flight (TOF) magnetic-resonance-angiography (MRA) identifies vessel pathology in cerebrovascular disease. At 7.0 T, the clinical performance of TOF-MRA is constrained owing to radiofrequency power deposition. We studied the diagnostic value of whole-brain MPRAGE-based MRA as an alternative imaging technique in comparison to the clinical standard 3.0 T TOF-MRA. Methods: Patients with stroke and/or moya-moya disease were included. TOF-MRA was performed at 3.0 T and MPRAGE-MRA at 7.0 T. Two radiologists rated the MRAs independently for overall quality and local arterial segment visualization. The identification of steno-occlusive pathology was reported for each protocol. Results: In 18 patients (9 females; 6 patients with moya-moya) 7.0 T MPRAGE-MRA provided better overall image quality and better distinction of small structures compared to 3.0 T TOF-MRA. These findings were pronounced in the proximal segments of the anterior cerebral artery (A1), middle cerebral artery (M1, M2), posterior cerebral artery (P1) and the posterior communicating artery. Seven steno-occlusive findings were identified by both imaging protocols. Conclusions: For clinical studies using ultrahigh field MRI, 7.0 T MPRAGE-MRA provides a suitable alternative to TOF-MRA imaging to identify brain vessel pathology and yields simultaneous structural brain imaging within clinically feasible acquisition times.
Keywords:Magnetic Resonance Imaging, 7 T MRI, Angiography, Cerebrovascular Disease, Diagnostic Imaging
Source:European Journal of Radiology
Page Range:2613-2617
Date:December 2015
Official Publication:https://doi.org/10.1016/j.ejrad.2015.09.021
PubMed:View item in PubMed

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