Does fludrocortisone influence autobiographical memory retrieval? A study in patients with major depression, patients with borderline personality disorder and healthy controls

Item Type:	Article
Title:	Does fludrocortisone influence autobiographical memory retrieval? A study in patients with major depression, patients with borderline personality disorder and healthy controls
Creators Name:	Fleischer, J. and Wingenfeld, K. and Kuehl, L.K. and Hinkelmann, K. and Roepke, S. and Otte, C.
Abstract:	There is evidence that stimulation of mineralocorticoid receptors (MR) enhances memory in healthy subjects and in patients with major depression (MDD). In contrast, in patients with borderline personality disorder (BPD), this effect seems to be task dependent. The aim of this study was to investigate the effect of MR stimulation on autobiographical memory retrieval in healthy individuals, patients with MDD, and patients with BPD. We conducted a placebo-controlled study in an intra-individual cross-over design. Twenty-four patients with MDD, 37 patients with BPD, and 67 healthy participants completed an autobiographical memory test after receiving 0.4 mg fludrocortisone, a mineralocorticoid receptor preferring agonist, or placebo in a randomized order. Healthy subjects, patients with MDD, and patients with BPD did not differ in their autobiographical memory retrieval. Furthermore, the administration of fludrocortisone had no effect on autobiographical memory. In conclusion, the stimulation of MR does not influence autobiographical memory retrieval in healthy subjects, patients with MDD, and patients with BPD. Our results do not support a role of MR in autobiographical memory.
Keywords:	Major Depression, Borderline Personality Disorder, Memory, Mineralocorticoid Receptor
Source:	Stress
ISSN:	1025-3890
Publisher:	Informa Healthcare
Volume:	18
Number:	6
Page Range:	718-722
Date:	November 2015
Official Publication:	https://doi.org/10.3109/10253890.2015.1087504
PubMed:	View item in PubMed

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