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B cell localization and migration in health and disease

Item Type:Book Section
Title:B cell localization and migration in health and disease
Creators Name:Hauser, A.E. and Höpken, U.E.
Abstract:B lymphocytes are a highly dynamic cell population. During their lifetime they travel over distances that are many times larger than their own size. Mature B cells constantly travel throughout the body, patrolling for antigens. This migration process is tightly regulated through a system of chemokines and adhesion molecules, which act like address codes to bring the B cells to their destination in various tissues. Moreover, already during their maturation process in the bone marrow, B cells of various developmental stages are undergoing distinct changes in their localization. This chapter focuses on the localization of various B cell subsets and on how their migration, adhesion, and interactions with tissue-resident stromal cells are regulated on a molecular level to ensure an efficient humoral immune response against pathogens. Apart from their role in protective immune responses, the same mechanisms that guide the motility of B cells can be detrimental under certain circumstances (e.g., in chronic inflammation and lymphoma dissemination).
Keywords:Adhesion Molecules, Bone Marrow, Chemokines, Lymphoma, Mucosal Tissues, Secondary Lymphoid Organs, Tertiary Lymphoid Organs
Source:Molecular Biology of B Cells (Second Edition)
Title of Book:Molecular Biology of B Cells
Publisher:Academic Press
Page Range:187-214
Official Publication:https://doi.org/10.1016/B978-0-12-397933-9.00012-6

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