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Periodic limb movements during REM sleep in multiple sclerosis: a previously undescribed entity

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Item Type:Article
Title:Periodic limb movements during REM sleep in multiple sclerosis: a previously undescribed entity
Creators Name:Veauthier, C. and Gaede, G. and Radbruch, H. and Sieb, J.P. and Wernecke, K.D. and Paul, F.
Abstract:Background: There are few studies describing periodic limb movement syndrome (PLMS) in rapid eye movement (REM) sleep in patients with narcolepsy, restless legs syndrome, REM sleep behavior disorder, and spinal cord injury, and to a lesser extent, in insomnia patients and healthy controls, but no published cases in multiple sclerosis (MS). The aim of this study was to investigate PLMS in REM sleep in MS and to analyze whether it is associated with age, sex, disability, and laboratory findings. Methods: From a study of MS patients originally published in 2011, we retrospectively analyzed periodic limb movements (PLMs) during REM sleep by classifying patients into two subgroups: PLM during REM sleep greater than or equal to ten per hour of REM sleep (n=7) vs less than ten per hour of REM sleep (n=59). A univariate analysis between PLM and disability, age, sex, laboratory findings, and polysomnographic data was performed. Results: MS patients with more than ten PLMs per hour of REM sleep showed a significantly higher disability measured by the Kurtzke expanded disability status scale (EDSS) (P=0.023). The presence of more than ten PLMs per hour of REM sleep was associated with a greater likelihood of disability (odds ratio 22.1; 95% confidence interval 3.5–139.7; P<0.0001), whereas there were no differences in laboratory and other polysomnographic findings. Conclusion: PLMs during REM sleep were not described in MS earlier, and they are associated with disability measured by the EDSS.
Keywords:Restless Legs Syndrome, Spinal Cord, Sleep Disorders, Disability, Clinical Neurophysiology, Polysomnography
Source:Neuropsychiatric Disease and Treatment
Publisher:Dove Medical Press
Page Range:2323-2329
Date:9 September 2015
Official Publication:https://doi.org/10.2147/NDT.S83350
PubMed:View item in PubMed

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