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Validation of the Erlangen score algorithm for the prediction of the development of dementia due to Alzheimer's disease in pre-dementia subjects

Item Type:Article
Title:Validation of the Erlangen score algorithm for the prediction of the development of dementia due to Alzheimer's disease in pre-dementia subjects
Creators Name:Lewczuk, P. and Kornhuber, J. and Toledo, J.B. and Trojanowski, J.Q. and Knapik-Czajka, M. and Peters, O. and Wiltfang, J. and Shaw, L.M.
Abstract:Background: In previous studies, a dichotomous stratification of subjects into "cerebrospinal fluid (CSF) normal" and "CSF pathologic" was used to investigate the role of biomarkers in the prediction of progression to dementia in pre-dementia/mild cognitive impairment subjects. With the previously published Erlangen Score Algorithm, we suggested a division of CSF patterns into five groups, covering all possible CSF result combinations based on the presence of pathologic tau and/or amyloid-{beta} CSF values. Objective: This study aimed to validate the Erlangen Score diagnostic algorithm based on the results of biomarkers analyses obtained in different patients cohorts, with different pre-analytical protocols, and with different laboratory analytical platforms. Methods: We evaluated the algorithm in two cohorts of pre-dementia subjects: the US-Alzheimer's Disease Neuroimaging Initiative and the German Dementia Competence Network. Results: In both cohorts, the Erlangen scores were strongly associated with progression to Alzheimer's disease. Neither the scores of the progressors nor the scores of the non-progressors differed significantly between the two projects, in spite of significant differences in the cohorts, laboratory methods, and the samples treatment. Conclusions: Our findings confirm the utility of the Erlangen Score algorithm as a useful tool in the early neurochemical diagnosis of Alzheimer's disease.
Keywords:Alzheimer's Disease, Biomarkers, Cerebrospinal Fluid, Clinical Neurochemistry, Results Interpretation, Validation
Source:Journal of Alzheimer's Disease
ISSN:1387-2877
Publisher:IOS Press (The Netherlands)
Volume:48
Number:2
Page Range:433-441
Date:9 September 2015
Additional Information:Erratum in: J Alzheimers Dis 49(3): 887.
Official Publication:https://doi.org/10.3233/JAD-150342
PubMed:View item in PubMed

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