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The B-cell antigen receptor integrates adaptive and innate immune signals

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Item Type:Article
Title:The B-cell antigen receptor integrates adaptive and innate immune signals
Creators Name:Otipoby, K.L. and Waisman, A. and Derudder, E. and Srinivasan, L. and Franklin, A. and Rajewsky, K.
Abstract:B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3{beta} and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.
Keywords:BCR, B-Cell Proliferation, PI-3K, GSK3{beta}, Foxo1, Animals, Mice
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences (U.S.A.)
Volume:112
Number:39
Page Range:12145-12150
Date:29 September 2015
Official Publication:https://doi.org/10.1073/pnas.1516428112
PubMed:View item in PubMed

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