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MAP kinase cascades in antigen receptor signaling and physiology

Item Type:Article
Title:MAP kinase cascades in antigen receptor signaling and physiology
Creators Name:Yasuda, T.
Abstract:Mitogen-activated protein kinases (MAPKs) play roles in a cell type and context-dependent manner to convert extracellular stimuli to a variety of cellular responses, thereby directing cells to proliferation, differentiation, survival, apoptosis, and migration. Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles among different families. MAPK cascades are obviously integrated in the B cell receptor signaling pathways as critical components to drive B cell-mediated immunity.
Keywords:B-Lymphocytes, Cellular Immunity, Extracellular Signal-Regulated MAP Kinases, MAP Kinase Signaling System, Animals
Source:Current Topics in Microbiology and Immunology
Publisher:Springer (U.S.A.)
Page Range:211-231
Official Publication:https://doi.org/10.1007/82_2015_481
PubMed:View item in PubMed

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