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IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia

Item Type:Article
Title:IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia
Creators Name:Harmon, A. and Cornelius, D. and Amaral, L. and Paige, A. and Herse, F. and Ibrahim, T. and Wallukat, G. and Faulkner, J. and Moseley, J. and Dechend, R. and LaMarca, B.
Abstract:OBJECTIVE: The reduced uterine perfusion pressure (RUPP) rat model of preeclampsia was used to determine the effects of added interleukin-10 (IL-10) on Tregs and hypertension in response to placental ischemia and how the decrease in these anti-inflammatory factors mediates the pathophysiology of preeclampsia. METHODS: IL-10 (2.5 ng/kg/d) was infused via osmotic mini-pump implanted intraperitoneally on day 14 of gestation and, at the same time, the RUPP procedure was performed. RESULTS: IL-10 reduced mean arterial pressure (p < 0.001), decreased CD4(+) T cells (p = 0.044), while increasing Tregs (p = 0.043) which led to lower IL-6 and TNF-alpha (p = 0.008 and p = 0.003), reduced AT1-AA production (p < 0.001), and decreased oxidative stress (p = 0.029) in RUPP rats. CONCLUSION: These data indicate that IL-10 supplementation increases Tregs and helps to balance the altered immune system seen during preeclampsia.
Keywords:Hypertension, Inflammation, Pregnancy, Animals, Rats
Source:Hypertension in Pregnancy
ISSN:1064-1955
Publisher:Informa Healthcare (U.S.A.)
Volume:34
Number:3
Page Range:291-306
Date:August 2015
Official Publication:https://doi.org/10.3109/10641955.2015.1032054
PubMed:View item in PubMed

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