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Omega-3 polyunsaturated fatty acids: the way forward in times of mixed evidence

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Item Type:Review
Title:Omega-3 polyunsaturated fatty acids: the way forward in times of mixed evidence
Creators Name:Weylandt, K.H. and Serini, S. and Chen, Y.Q. and Su, H.M. and Lim, K. and Cittadini, A. and Calviello, G.
Abstract:Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several clinical cardiovascular studies demonstrated the beneficial health effects of omega-3 PUFA, leading medical institutions worldwide to publish recommendations for their increased intake. However, particularly in recent years, contradictory results have been obtained in human studies focusing on cardiovascular disease and the clinical evidence in other diseases, particularly chronic inflammatory and neoplastic diseases, was never established to a degree that led to clear approval of treatment with omega-3 PUFA. Recent data not in line with the previous findings have sparked a debate on the health efficacy of omega-3 PUFA and the usefulness of increasing their intake for the prevention of a number of pathologies. In this review, we aim to examine the controversies on the possible use of these fatty acids as preventive/curative tools against the development of cardiovascular, metabolic, and inflammatory diseases, as well as several kinds of cancer.
Keywords:Cardiovascular Diseases, Diet, Fish Oils, Obesity, Omega-3 Fatty Acids, Risk Factors, Animals
Source:BioMed Research International
Page Range:143109
Date:2 August 2015
Official Publication:https://doi.org/10.1155/2015/143109
PubMed:View item in PubMed

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