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Intake of meat mutagens and risk of prostate cancer in a cohort of U.S. health professionals

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Item Type:Article
Title:Intake of meat mutagens and risk of prostate cancer in a cohort of U.S. health professionals
Creators Name:Rohrmann, S. and Nimptsch, K. and Sinha, R. and Willett, W.C. and Giovannucci, E.L. and Platz, E.A. and Wu, K.
Abstract:BACKGROUND: Evidence relating heterocyclic aromatic amines (HCA), associated with high-temperature cooking methods, to prostate cancer risk is inconsistent Methods: In a large US cohort study, intakes of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and a meat-derived mutagenicity index (MDM) were assessed using a cooking method questionnaire administered in 1996. Until 2010, 2,770 prostate cancer cases were observed among 26,030 participants. RESULTS: Intake of PhIP from red meat was statistically significantly associated with total prostate cancer risk (top vs. bottom quintile HR=1.18, 95% CI 1.03-1.35), but not other HCAs (MeIQx, 1.12, 0.98-1.27, PhIP from white meat, 1.07, 0.94-1.21, DiMeIQx, 1.09, 0.97-1.21) or MDM (1.13, 1.00-1.28). For high grade (Gleason sum 7 with pattern 4+3 and Gleason sum 8-10, n=483 cases) and advanced cancers (n=281), we only observed positive associations for PhIP from red meat (top vs. bottom quintile: high grade: HR=1.44, 95% CI 1.04-1.98, p-trend=0.03; advanced: HR=1.50, 95% 0.99-2.26; p-trend=0.12), but associations for advanced cancers did not reach statistical significance. Observed associations remained similar after adjustment for total, unprocessed or processed red meat intake. CONCLUSION: Observed positive associations between PhIP intake from red meat and prostate cancer, particularly high-grade and possibly also advanced prostate cancer need to be confirmed in other studies. IMPACT: Results do not provide strong evidence that HCAs increase risk of prostate cancers.
Keywords:Benzimidazoles, Cooking, Feeding Behavior, Follow-Up Studies, Health Personnel, Imidazoles, Incidence, Meat, Mutagens, Prostatic Neoplasms, Quinoxalines, Reproducibility of Results, Retrospective Studies, Risk Assessment, Risk Factors, Surveys and Questionnaires, United States
Source:Cancer Epidemiology, Biomarkers & Prevention
Publisher:American Association for Cancer Research
Page Range:1557-1563
Date:October 2015
Official Publication:https://doi.org/10.1158/1055-9965.EPI-15-0068-T
PubMed:View item in PubMed

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