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The ERGonomics of hematopoietic stem cell self-renewal

Item Type:Article
Title:The ERGonomics of hematopoietic stem cell self-renewal
Creators Name:Lacadie, S.A. and Zon, L.I.
Abstract:Stem cells make more of themselves by self-renewing cell divisions. In the February 1, 2011, issue of Genes and Development, Taoudi and colleagues (pp. 251-262) show an essential role for the ETS transcription factor ERG in the self-renewal of embryonic hematopoietic stem cells. A model is presented in which the redundant functions of GATA2 and RUNX1 in self-renewal are under direct control of ERG.
Keywords:ERG, ETS Family Transcription Factors, Gata2, Hematopoietic Development, Hematopoietic Stem Cells, Runx1, Self-Renewal
Source:Genes & Development
ISSN:0890-9369
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Volume:25
Number:4
Page Range:289-293
Date:15 February 2011
Official Publication:https://doi.org/10.1101/gad.2031511
PubMed:View item in PubMed

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