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Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis

Item Type:Article
Title:Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis
Creators Name:Pfuhl, C. and Oechtering, J. and Rasche, L. and Gieß, R.M. and Behrens, J.R. and Wakonig, K. and Freitag, E. and Pache, F.C. and Otto, C. and Hofmann, J. and Eberspächer, B. and Bellmann-Strobl, J. and Paul, F. and Ruprecht, K.
Abstract:Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synthesis of immunoglobulin (Ig)G. In 90 patients with clinically isolated syndromes/early relapsing-remitting MS, serum antibodies to Epstein-Barr nuclear antigen-1, but not to EBV viral capsid antigen, rubella, or varicella zoster virus, were higher (p=0.03) in those with than those without a calculated intrathecal IgG synthesis >0% and correlated with the percentage (r=0.27, p=0.009) and concentration (r=0.27, p=0.012) of intrathecally produced IgG. These findings suggest a link between EBV infection and the events leading to intrathecal IgG synthesis in patients with MS.
Keywords:Multiple Sclerosis, Epstein–Barr Virus, Intrathecal Immunoglobulin G, Oligoclonal Bands, Epstein-Barr Nuclear Antigen-1, Antibodies
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier (The Netherlands)
Volume:285
Page Range:156-160
Date:15 August 2015
Official Publication:https://doi.org/10.1016/j.jneuroim.2015.06.012
PubMed:View item in PubMed

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