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| Item Type: | Article |
|---|---|
| Title: | Sleep disorders reduce health-related quality of life in multiple sclerosis (Nottingham Health Profile data in patients with multiple sclerosis) |
| Creators Name: | Veauthier, C. and Gaede, G. and Radbruch, H. and Wernecke, K.D. and Paul, F. |
| Abstract: | Quality of Life (QoL) is decreased in multiple sclerosis (MS), but studies about the impact of sleep disorders (SD) on health-related quality of Life (HRQoL) are lacking. From our original cohort, a cross-sectional polysomnographic (PSG) study in consecutive MS patients, we retrospectively analysed the previously unpublished data of the Nottingham Health Profile (NHP). Those MS patients suffering from sleep disorders (n = 49) showed significantly lower HRQoL compared to MS patients without sleep disorders (n = 17). Subsequently, we classified the patients into four subgroups: insomnia (n = 17), restless-legs syndrome, periodic limb movement disorder and SD due to leg pain (n = 24), obstructive sleep apnea (n = 8) and patients without sleep disorder (n = 17). OSA and insomnia patients showed significantly higher NHP values and decreased HRQoL not only for the sleep subscale but also for the "energy" and "emotional" area of the NHP. In addition, OSA patients also showed increased NHP values in the "physical abilities" area. Interestingly, we did not find a correlation between the objective PSG parameters and the subjective sleep items of the NHP. However, this study demonstrates that sleep disorders can reduce HRQoL in MS patients and should be considered as an important confounder in all studies investigating HRQoL in MS. |
| Keywords: | Restless Legs Syndrome, Sleep Disorders, Multiple Sclerosis, Clinical Neurophysiology, Polysomnography, Insomnia, Pain, Depression, Health, Quality Of Life |
| Source: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Publisher: | MDPI |
| Volume: | 16 |
| Number: | 7 |
| Page Range: | 16514-16528 |
| Date: | 21 July 2015 |
| Official Publication: | https://doi.org/10.3390/ijms160716514 |
| PubMed: | View item in PubMed |
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