Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Importin-α7 is involved in the formation of Ebola virus inclusion bodies but is not essential for pathogenicity in mice

Item Type:Article
Title:Importin-α7 is involved in the formation of Ebola virus inclusion bodies but is not essential for pathogenicity in mice
Creators Name:Gabriel, G., Feldmann, F., Reimer, R., Thiele, S., Fischer, M., Hartmann, E., Bader, M., Ebihara, H., Hoenen, T. and Feldmann, H.
Abstract:Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-{alpha} isoforms. Thereby, it blocks STAT1-mediated IFN-{alpha}/{beta} and IFN-{gamma} synthesis. However, owing to the lack of importin-{alpha} knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-{alpha}7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-{alpha}7 was not sufficient to increase survival rates among mice infected with EBOV.
Keywords:Ebola Virus, Importin-{alpha}, Inclusion Bodies, Pathogenicity, VP24, Interferon, STAT1, Animals, Mice
Source:Journal of Infectious Diseases
ISSN:0022-1899
Publisher:Oxford University Press
Volume:212
Number:Suppl 2
Page Range:S316-S321
Date:1 October 2015
Official Publication:https://doi.org/10.1093/infdis/jiv240
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library