Importin-α7 is involved in the formation of Ebola virus inclusion bodies but is not essential for pathogenicity in mice

Item Type:	Article
Title:	Importin-α7 is involved in the formation of Ebola virus inclusion bodies but is not essential for pathogenicity in mice
Creators Name:	Gabriel, G. and Feldmann, F. and Reimer, R. and Thiele, S. and Fischer, M. and Hartmann, E. and Bader, M. and Ebihara, H. and Hoenen, T. and Feldmann, H.
Abstract:	Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-{alpha} isoforms. Thereby, it blocks STAT1-mediated IFN-{alpha}/{beta} and IFN-{gamma} synthesis. However, owing to the lack of importin-{alpha} knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-{alpha}7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-{alpha}7 was not sufficient to increase survival rates among mice infected with EBOV.
Keywords:	Ebola Virus, Importin-{alpha}, Inclusion Bodies, Pathogenicity, VP24, Interferon, STAT1, Animals, Mice
Source:	Journal of Infectious Diseases
ISSN:	0022-1899
Publisher:	Oxford University Press
Volume:	212
Number:	Suppl 2
Page Range:	S316-S321
Date:	1 October 2015
Official Publication:	https://doi.org/10.1093/infdis/jiv240
PubMed:	View item in PubMed

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